View source for Pro-cathepsin H

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{{#invoke:InfoboxforTarget|run|CTSH|[https://www.uniprot.org/uniprot/P09668 P09668]|Homo sapiens|Cys141|[http://pfam.xfam.org/family/PF00112 Peptidase C1 family]|[[:Category:Pro-cathepsin H|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Cathepsin H is a lysosomal cysteine proteinase, belongs to the peptidase C1 protein family. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The protein can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. (From Wikipedia)<br/>
Important for the overall degradation of proteins in lysosomes. Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase. (From Uniprot) 
<br/>

===Cys Function & Property===
Cys141 is one of the active sites of Cathepsin H, which is very close to His281 and Asn301 in space. These three residues formed a typical catalytic triad motif.<br/>

* Hydrophobic property:
:[[File:489-hydro.png||600px]]
* SASA：
:Cys141: 1.32 A^2

==Protein Sequence==
<font face="Courier">
MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE <br/>
YHHRLQTFAS NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ <br/>
NCSATKSNYL RGTGPYPPSV DWRKKGNFVS PVKNQGACGS <span style="background:#ffff00">'''C'''</span>WTFSTTGAL <br/>
ESAIAIATGK MLSLAEQQLV DCAQDFNNHG CQGGLPSQAF EYILYNKGIM <br/>
GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV EAVALYNPVS <br/>
FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK <br/>
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV                 <br/> 
</font>

==Structural Information==
*Known structures with covalent ligands: <br/>
:Unknown<br/>   

*Protein structure:
[[File:489.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko04142 Lysosome] <br/>
*[https://www.genome.jp/kegg-bin/show_pathway?ko04210 Apoptosis] <br/>

==Experimental Evidence==
:Homologous Analysis of Sequence, Enzymatic Assay 

==Reference==
# Štern I, Schaschke N, Moroder L, et al. '''Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft[J].''' Biochemical Journal, 2004, 381(2): 511-517. [https://www.ncbi.nlm.nih.gov/pubmed/?term=15084146 15084146]<br/>

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Protease]]
[[Category:Peptidase C1 family]]
[[Category:Lysosome]]
[[Category:Apoptosis]]