View source for Sentrin-specific protease 2

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{{#invoke:InfoboxforTarget|run|SENP2|[https://www.uniprot.org/uniprot/Q9HC62 Q9HC62]|Homo sapiens|Cys548|[http://pfam.xfam.org/family/PF02902 Peptidase C48 family]|[[:Category:Sentrin-specific protease 2|Ligand list]]|Protease}}
==Summary==

===Protein Function ===
Sentrin-specific protease 2 (SENP2) is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. (From Wikipedia)<br/>
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. (From Uniprot)<br/>

===Cys Function & Property===
Cys548 is one of the active sites of SENP1. <br/>

* Hydrophobic property:
:[[File:577-hydro.png||600px]]
* SASA:
:Cys548: 2.987 A^2<br/>

==Protein Sequence==
<font face="Courier">
MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP <br/> 
RLDCFIHQVK NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS <br/> 
NSSSCELTGS GSWNNMLKLG NKSPNGISDY PKIRVTVTRD QPRRVLPSFG <br/> 
FTLNSEGCNR RPGGRRHSKG NPESSLMWKP QEQAVTEMIS EESGKGLRRP <br/> 
HCTVEEGVQK EEREKYRKLL ERLKESGHGN SVCPVTSNYH SSQRSQMDTL <br/> 
KTKGWGEEQN HGVKTTQFVP KQYRLVETRG PLCSLRSEKR CSKGKITDTE <br/> 
TMVGIRFENE SRRGYQLEPD LSEEVSARLR LGSGSNGLLR RKVSIIETKE <br/> 
KNCSGKERDR RTDDLLELTE DMEKEISNAL GHGPQDEILS SAFKLRITRG <br/> 
DIQTLKNYHW LNDEVINFYM NLLVERNKKQ GYPALHVFST FFYPKLKSGG <br/> 
YQAVKRWTKG VNLFEQEIIL VPIHRKVHWS LVVIDLRKKC LKYLDSMGQK <br/> 
GHRICEILLQ YLQDESKTKR NSDLNLLEWT HHSMKPHEIP QQLNGSD<span style="background:#ffff00">'''C'''</span>GM <br/> 
FTCKYADYIS RDKPITFTQH QMPLFRKKMV WEILHQQLL        <br/> 
</font>

==Structural Information==
*Known structure with covalent ligand: <br/>
:Unknown<br/>  

*Protein structure:
:[[File:577.png|center|800px]]

==Related Pathway==
*[https://www.genome.jp/kegg-bin/show_pathway?ko03013 RNA transport] <br/>
*[https://www.genome.jp/kegg-bin/show_pathway?ko04310 Wnt signaling pathway] <br/>	

==Experimental Evidence==
:Molecular Docking, Homologous Analysis of Sequence   

==Reference==
# Ponder E L, Albrow V E, Leader B A, et al. '''Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors[J].''' Chemistry & biology, 2011, 18(6): 711-721. [https://www.ncbi.nlm.nih.gov/pubmed/?term=21700207 21700207]<br/>

[[Category:Targets]]
[[Category:Homo sapiens]]
[[Category:Protease]]
[[Category:Peptidase C48 family]]
[[Category:NR3 subfamily]]
[[Category:RNA transport]]
[[Category:Wnt signaling pathway]]