Cysteinome

Cysteine is an unique amino acid with the thiol side chain serving as an intrinsic nucleophile and often participating in various enzymatic reactions. In recent years, covalent probes or inhibitors homing at a cysteine thiol group present in the target proteins have attracted significant attention. But the lack of systematic information for proteins with targetable cysteine has hindered the design and discovery of covalent modulators of protein functions and activities. Therefore, a comprehensive database with an analysis system dedicated to proteins with targetable cysteine could be very useful.
Cysteinome, the first online database that provides a rich resource for the display, search and analysis of structure, function and related annotation for proteins with targetable cysteine as well as their covalent modulators. It could contribute to the understanding of how protein targets are covalently modified by chemical probes homing at cysteine residues and will serve as a useful resource for the design and development of covalent inhibitors.

Announcement

Old version cysteinome.org website is offline now, and I am trying to recover the database by the Wiki site: www.cysteinome.net/Cysteinome. If you have any question or suggestion, please feel free to connect me:

wu.3857 AT osu.edu OR sijin.wu84 AT gmail.com

If you find Cysteinome useful, please consider citing the reference:

Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors[J]. Biochemical and biophysical research communications, 2016, 478(3): 1268-1273.

Category

• Targets

• Species
• Pathway
• Function type
• Protein Family/Domain

• Ligands

• Ligand type
• Bond type
• Ligand list