Difference between revisions of "Arginase-1 (Rattus norvegicus)"
(Created page with "{| align="left" | __TOC__ |} {{#invoke:InfoboxforTarget|run|Arg1|[https://www.uniprot.org/uniprot/P07824 P07824]|Rattus norvegicus|Cys119, Cys168, Cys303|[http://pfam.xfam...") |
(→Reference) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 10: | Line 10: | ||
===Cys Function & Property=== | ===Cys Function & Property=== | ||
| − | |||
* Hydrophobic property: | * Hydrophobic property: | ||
| Line 18: | Line 17: | ||
:Cys168: 15.433 A^2 <br/> | :Cys168: 15.433 A^2 <br/> | ||
:Cys303: 0.158 A^2 <br/> | :Cys303: 0.158 A^2 <br/> | ||
| − | |||
==Protein Sequence== | ==Protein Sequence== | ||
| Line 51: | Line 49: | ||
# Kanda H, Sumi D, Endo A, et al. '''Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism[J].''' Archives of toxicology, 2008, 82(11): 803. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18488197 18488197]<br/> | # Kanda H, Sumi D, Endo A, et al. '''Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism[J].''' Archives of toxicology, 2008, 82(11): 803. [https://www.ncbi.nlm.nih.gov/pubmed/?term=18488197 18488197]<br/> | ||
| − | [[Category: | + | [[Category:Targets]] |
| − | [[Category: | + | [[Category:Rattus norvegicus]] |
| − | [[Category: | + | [[Category:Metabolic enzyme]] |
| − | [[Category: | + | [[Category:Arginase family]] |
| − | [[Category: | + | [[Category:Arginine biosynthesis]] |
| − | [[Category: | + | [[Category:Metabolic pathways]] |
| − | [[Category: | + | [[Category:Arginine and proline metabolism]] |
| − | [[Category: | + | [[Category:Biosynthesis of amino acids]] |
| − | [[Category: | + | [[Category:Amoebiasis]] |
Latest revision as of 21:38, 19 August 2019
| Basic Information | |
|---|---|
| Short Name | Arg1 |
| UNP ID | P07824 |
| Organism | Rattus norvegicus |
| Cys Site | Cys119, Cys168, Cys303 |
| Family/Domain | Arginase family |
| Known Ligand | Ligand list |
| Function Type | Metabolic enzyme |
Summary
Protein Function
Arginase, belongs to the ureohydrolase family of enzymes, which catalyses the conversion of arginine to urea and ornithine, exists as two distinct isoforms (arginase I and arginase II). Arginase I is expressed almost exclusively in the liver where it serves as an essential enzyme of the urea cycle, while arginase II is expressed in the kidney and many other extrahepatic tissues. Arginase catalyzes the fifth and final step in the urea cycle, a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. Specifically, arginase converts L-arginine into L-ornithine and urea. (From Wikipedia, PMID: 18488197)
Cys Function & Property
- Hydrophobic property:
- SASA：
- Cys119: 0 A^2
- Cys168: 15.433 A^2
- Cys303: 0.158 A^2
Protein Sequence
MSSKPKPIEI IGAPFSKGQP RGGVEKGPAA LRKAGLVEKL KETEYNVRDH
GDLAFVDVPN DSPFQIVKNP RSVGKANEQL AAVVAETQKN GTISVVLGGD
HSMAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTSSGNL HGQPVAFLLK
ELKGKFPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYII KTLGIKYFSM
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPVF TPATGTPVVG
GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTPEEVT RTVNTAVALT
LSCFGTKREG NHKPETDYLK PPK
Structural Information
- Known structure with covalent ligand:
- Unknown
- Protein structure:
Related Pathway
- Arginine biosynthesis
- Arginine and proline metabolism
- Metabolic pathways
- Biosynthesis of amino acids
- Amoebiasis
Experimental Evidence
- Homologous Analysis of Sequence, Cys Modification Assay
Reference
- Kanda H, Sumi D, Endo A, et al. Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism[J]. Archives of toxicology, 2008, 82(11): 803. 18488197
