Difference between revisions of "Serum albumin"
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| − | {{#invoke:InfoboxforTarget|run|ALB, HAS|[https://www.uniprot.org/uniprot/P02768 P02768]|Homo sapiens|Cys58|ALB/AFP/VDB family|[[:Category:Serum albumin|Ligand list]]}} | + | {{#invoke:InfoboxforTarget|run|ALB, HAS|[https://www.uniprot.org/uniprot/P02768 P02768]|Homo sapiens|Cys58|[http://pfam.xfam.org/family/PF00273 Serum albumin family], ALB/AFP/VDB family|[[:Category:Serum albumin|Ligand list]]|Transporter}} |
==Summary== | ==Summary== | ||
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==Reference== | ==Reference== | ||
| − | #Antunes A M M, Godinho A L A, Martins I L, et al. '''Protein adducts as prospective biomarkers of nevirapine toxicity[J].''' Chemical research in toxicology, 2010, 23(11): 1714-1725.[https://www.ncbi.nlm.nih.gov/pubmed/?term=20809596 20809596]<br/> | + | #Antunes A M M, Godinho A L A, Martins I L, et al. '''Protein adducts as prospective biomarkers of nevirapine toxicity[J].''' Chemical research in toxicology, 2010, 23(11): 1714-1725. [https://www.ncbi.nlm.nih.gov/pubmed/?term=20809596 20809596]<br/> |
| − | #Jagadish B, Guntle G P, Zhao D, et al. '''Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J].''' Journal of medicinal chemistry, 2012, 55(23): 10378-10386.[https://www.ncbi.nlm.nih.gov/pubmed/?term=23148501 23148501]<br/> | + | #Jagadish B, Guntle G P, Zhao D, et al. '''Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J].''' Journal of medicinal chemistry, 2012, 55(23): 10378-10386. [https://www.ncbi.nlm.nih.gov/pubmed/?term=23148501 23148501]<br/> |
[[Category:Targets]] | [[Category:Targets]] | ||
[[Category:Homo sapiens]] | [[Category:Homo sapiens]] | ||
| + | [[Category:Serum albumin family]] | ||
[[Category:ALB/AFP/VDB family]] | [[Category:ALB/AFP/VDB family]] | ||
| + | [[Category:Transporter]] | ||
[[Category:Thyroid hormone synthesis]] | [[Category:Thyroid hormone synthesis]] | ||
Latest revision as of 01:54, 2 December 2019
| Basic Information | |
|---|---|
| Short Name | ALB, HAS |
| UNP ID | P02768 |
| Organism | Homo sapiens |
| Cys Site | Cys58 |
| Family/Domain | Serum albumin family, ALB/AFP/VDB family |
| Known Ligand | Ligand list |
| Function Type | Transporter |
Summary
Protein Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. (From Uniprot)
Serum albumin is produced by the liver, occurs dissolved in blood plasma and is the most abundant blood protein in mammals. Albumin is essential for maintaining the oncotic pressure needed for proper distribution of body fluids between blood vessels and body tissues. It functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones in the blood and plays a major role in stabilizing extracellular fluid volume by contributing to oncotic pressure (known also as colloid osmotic pressure) of plasma. (From Wikipedia)
Cys Function & Property
Cys58 is close to the active sites of ALB, which is consisted by Tyr108, His63, and Asp62.
- Hydrophobic property:
- SASA：
- Cys58: 8.879 A^2
Protein Sequence
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA
FAQYLQQGCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT
VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA
FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA
CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA
EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF
LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE
FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV
SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC
CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ
TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV
AASQAALGL
Structural Information
- Known structures with covalent ligands:
- Unknown
- Protein structure:
Related Pathway
Experimental Evidence
- LC-ESI-MS/MS, MALDI-TOF-TOF-MS, Tryptic Digest, 2D 1H−1H NMR TOCSY
Reference
- Antunes A M M, Godinho A L A, Martins I L, et al. Protein adducts as prospective biomarkers of nevirapine toxicity[J]. Chemical research in toxicology, 2010, 23(11): 1714-1725. 20809596
- Jagadish B, Guntle G P, Zhao D, et al. Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J]. Journal of medicinal chemistry, 2012, 55(23): 10378-10386. 23148501
