Difference between revisions of "Solute carrier family 22 member 5"

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{{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81,<br/>Cys113, Cys136|[http://pfam.xfam.org/family/PF00083 Sugar (and other) transporter],<br/>Major facilitator (TC 2.A.1) superfamily,<br/> Organic cation transporter (TC 2.A.1.19) family|[[:Category:Solute carrier family 22 member 5|Ligand list]]}}
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{{#invoke:InfoboxforTarget|run|OCTN2, CT1, Ust2r|[https://www.uniprot.org/uniprot/O70594 O70594]|Rattus norvegicus|Cys50, Cys81,<br/>Cys113, Cys136|[http://pfam.xfam.org/family/PF00083 Sugar (and other) transporter],<br/>Major facilitator (TC 2.A.1) superfamily,<br/> Organic cation transporter (TC 2.A.1.19) family|[[:Category:Solute carrier family 22 member 5|Ligand list]]|Transporter}}
 
==Summary==
 
==Summary==
  
 
===Protein Function ===
 
===Protein Function ===
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This protein is a sodium-ion dependent, high affinity carnitine transporter, which involved in the active cellular uptake of carnitine. It could transport one sodium ion with one molecule of carnitine, and also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. (From Uniprot)
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This protein is a sodium-ion dependent, high affinity carnitine transporter, which involved in the active cellular uptake of carnitine. It could transport one sodium ion with one molecule of carnitine, and also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. (From Uniprot)
 
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==Related Pathway==
 
==Related Pathway==
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*[https://www.genome.jp/kegg-bin/show_pathway?rno05231 Choline metabolism in cancer]
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*[https://www.genome.jp/kegg-bin/show_pathway?ko05231 Choline metabolism in cancer]<br/>
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<br/>
 
  
 
==Experimental Evidence==
 
==Experimental Evidence==
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# Pochini L, Peta V, Indiveri C. '''Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity[J].''' Toxicology mechanisms and methods, 2013, 23(2): 68-76. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22900493 22900493]<br/>
 
# Pochini L, Peta V, Indiveri C. '''Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity[J].''' Toxicology mechanisms and methods, 2013, 23(2): 68-76. [https://www.ncbi.nlm.nih.gov/pubmed/?term=22900493 22900493]<br/>
  
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[[Category:Targets|Targets]]
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[[Category:Targets]]
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[[Category:Rattus norvegicus|Rattus norvegicus]]
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[[Category:Rattus norvegicus]]
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[[Category:Major facilitator (TC 2.A.1) superfamily|Major facilitator (TC 2.A.1) superfamily]]
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[[Category:Transporter]]
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[[Category:Organic cation transporter (TC 2.A.1.19) family|Organic cation transporter (TC 2.A.1.19) family]]
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[[Category:Major facilitator (TC 2.A.1) superfamily]]
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[[Category:Sugar (and other) transporter|Sugar (and other) transporter]]
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[[Category:Organic cation transporter (TC 2.A.1.19) family]]
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[[Category:Choline metabolism in cancer|Choline metabolism in cancer]]
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[[Category:Sugar (and other) transporter]]
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[[Category:Choline metabolism in cancer]]

Latest revision as of 23:15, 19 August 2019

Basic Information
Short Name OCTN2, CT1, Ust2r
UNP ID O70594
Organism Rattus norvegicus
Cys Site Cys50, Cys81,
Cys113, Cys136
Family/Domain Sugar (and other) transporter,
Major facilitator (TC 2.A.1) superfamily,
Organic cation transporter (TC 2.A.1.19) family
Known Ligand Ligand list
Function Type Transporter

Summary

Protein Function

This protein is a sodium-ion dependent, high affinity carnitine transporter, which involved in the active cellular uptake of carnitine. It could transport one sodium ion with one molecule of carnitine, and also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. (From Uniprot)

Cys Function & Property

These cysteines are located on the extracellular domain, as shown below.

495-function.png
  • Hydrophobic property:
495-hydro.png
  • SASA：
Unknown

Protein Sequence

MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFNGMSIV FLAGTPEHRC
LVPHTVNLSS AWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSALGLEPG
RDVDLEQLEQ ENCLDGWEYN KDVFLSTIVT EWDLVCKDDW KAPLTTSLFF
VGVLMGSFIS GQLSDRFGRK NVLFLTMGMQ TGFSFLQLFS VNFEMFTVLF
VLVGMGQISN YVAAFVLGTE ILSKSIRIIF ATLGVCIFYA FGFMVLPLFA
YFIRDWRMLL LALTVPGVLC GALWWFIPES PRWLISQGRV KEAEVIIRKA
AKFNGIVAPS TIFDPSELQD LNSKKPQSHH IYDLVRTRNI RIITIMSIIL
WLTISVGYFG LSLDTPNLHG DIYVNCFLLA AVEVPAYVLA WLLLQHLPRR
YSISAALFLG GSVLLFIQLV PSELFYLSTA LVMVGKFGIT SAYSMVYVYT
AELYPTVVRN MGVGVSSTAS RLGSILSPYF VYLGAYDRFL PYILMGSLTI
LTAILTLFFP ESFGAPLPDT IDQMLRVKGI KQWQIQSQTR TQKDGGESPT
VLKSTAF

Structural Information

  • Known structures with covalent ligands:
Unknown
  • Protein structure:
Unknown

Related Pathway

Experimental Evidence

Crystallography, Homologous Analysis of Sequence

Reference

  1. Pochini L, Scalise M, Indiveri C. Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes[J]. Chemico-biological interactions, 2009, 179(2-3): 394-401. 19041296
  2. Pochini L, Peta V, Indiveri C. Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity[J]. Toxicology mechanisms and methods, 2013, 23(2): 68-76. 22900493
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