Difference between revisions of "Cathepsin S"
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# Pauly T A, Sulea T, Ammirati M, et al. '''Specificity determinants of human cathepsin S revealed by crystal structures of complexes[J].''' Biochemistry, 2003, 42(11): 3203-3213. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12641451 12641451]<br/> | # Pauly T A, Sulea T, Ammirati M, et al. '''Specificity determinants of human cathepsin S revealed by crystal structures of complexes[J].''' Biochemistry, 2003, 42(11): 3203-3213. [https://www.ncbi.nlm.nih.gov/pubmed/?term=12641451 12641451]<br/> | ||
| − | # Cai J, Baugh M, Black D, et al. '''6-Phenyl-1H-imidazo [4, 5-c] pyridine-4-carbonitrile as cathepsin S inhibitors[J].''' Bioorganic & | + | # Cai J, Baugh M, Black D, et al. '''6-Phenyl-1H-imidazo [4, 5-c] pyridine-4-carbonitrile as cathepsin S inhibitors[J].''' Bioorganic & Medicinal Chemistry Letters, 2010, 20(15): 4350-4354. [https://www.ncbi.nlm.nih.gov/pubmed/?term=20598883 20598883]<br/> |
| − | # Inagaki H, Tsuruoka H, Hornsby M, et al. '''Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode[J].''' Journal of | + | # Inagaki H, Tsuruoka H, Hornsby M, et al. '''Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode[J].''' Journal of Medicinal Chemistry, 2007, 50(11): 2693-2699. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17469812 17469812]<br/> |
| − | # Bekkali Y, Thomson D S, Betageri R, et al. '''Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J].''' Bioorganic & | + | # Bekkali Y, Thomson D S, Betageri R, et al. '''Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J].''' Bioorganic & Medicinal Chemistry Letters, 2007, 17(9): 2465-2469. [https://www.ncbi.nlm.nih.gov/pubmed/?term=17379516 17379516]<br/> |
Revision as of 04:24, 28 July 2019
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Summary
Protein Function
Cathepsin S is a thiol protease, which act as key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. (From Uniprot)
Cys Function & Property
Cys139 is one of the active sites of Cathepsin S, which is very close to His278 and Asn298 in space. These three residues formed a typical catalytic triad motif.
- Hydrophobic property:
- SASA：
- Cys139: 11.884 A^2
Protein Sequence
MKRLVCVLLV CSSAVAQLHK DPTLDHHWHL WKKTYGKQYK EKNEEAVRRL
IWEKNLKFVM LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPSQ
WQRNITYKSN PNRILPDSVD WREKGCVTEV KYQGSCGACW AFSAVGALEA
QLKLKTGKLV SLSAQNLVDC STEKYGNKGC NGGFMTTAFQ YIIDNKGIDS
DASYPYKAMD QKCQYDSKYR AATCSKYTEL PYGREDVLKE AVANKGPVSV
GVDARHPSFF LYRSGVYYEP SCTQNVNHGV LVVGYGDLNG KEYWLVKNSW
GHNFGEEGYI RMARNKGNHC GIASFPSYPE I
Structural Information
- Known structures with covalent ligands:
- Protein structure
Related Pathway
Experimental Evidence
- Crystallography, Cys-directed mutation, Homologous Analysis of Sequence, Enzymatic Assay
Reference
- Pauly T A, Sulea T, Ammirati M, et al. Specificity determinants of human cathepsin S revealed by crystal structures of complexes[J]. Biochemistry, 2003, 42(11): 3203-3213. 12641451
- Cai J, Baugh M, Black D, et al. 6-Phenyl-1H-imidazo [4, 5-c] pyridine-4-carbonitrile as cathepsin S inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20(15): 4350-4354. 20598883
- Inagaki H, Tsuruoka H, Hornsby M, et al. Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode[J]. Journal of Medicinal Chemistry, 2007, 50(11): 2693-2699. 17469812
- Bekkali Y, Thomson D S, Betageri R, et al. Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2007, 17(9): 2465-2469. 17379516
