Caspase-5

Basic Information
Short Name	CASP5
UNP ID	P51878
Organism	Homo sapiens
Cys Site	Cys315
Family/Domain	Peptidase C14A family
Known Ligand	Ligand list
Function Type	Protease

Summary

Protein Function

Caspase-5 is a member of the cysteine-aspartic acid protease (caspase) family. It is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue y (preferred cleavage after Trp-GluXaa-Asp).
It is an inflammatory caspase, along with caspase-1, caspase-4 and the murine caspase-4 homolog caspase-11, and has a role in the immune system. (From Wikipedia, PMID: 22014003)

Cys Function & Property

The catalytic triad in Caspase-5 comprises Cys315, His267 and Arg221 by similarity.

• Hydrophobic property:

• SASA:

Cys315: Unknown

Protein Sequence

MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP
NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK
KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE
AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN
TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA
RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK
IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF
RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN

Structural Information

• Known structure with covalent ligand:
  

Unknown

• Protein structure:

Unknown

Related Pathway

• NOD-like receptor signaling pathway
  

Experimental Evidence

Similarity, Site-directed mutation assasy

Reference

1. Gao J, Wells J A. Identification of specific tethered inhibitors for caspase‐5[J]. Chemical biology & drug design, 2012, 79(2): 209-215. 22014003