Serum albumin

Summary

Protein Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. (From Uniprot)
Serum albumin is produced by the liver, occurs dissolved in blood plasma and is the most abundant blood protein in mammals. Albumin is essential for maintaining the oncotic pressure needed for proper distribution of body fluids between blood vessels and body tissues. It functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones in the blood and plays a major role in stabilizing extracellular fluid volume by contributing to oncotic pressure (known also as colloid osmotic pressure) of plasma. (From Wikipedia)

Cys Function & Property

Cys58 is close to the active sites of ALB, which is consisted by Tyr108, His63, and Asp62.

• Hydrophobic property:

• SASA：

Cys58: 8.879 A^2

Protein Sequence

MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA
FAQYLQQGCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT
VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA
FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA
CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA
EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF
LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE
FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV
SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC
CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ
TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV
AASQAALGL

Structural Information

• Known structures with covalent ligands:
  

Unknown

• Protein structure:

Related Pathway

• Thyroid hormone synthesis
  

Experimental Evidence

LC-ESI-MS/MS, MALDI-TOF-TOF-MS, Tryptic Digest, 2D 1H−1H NMR TOCSY

Reference

1. Antunes A M M, Godinho A L A, Martins I L, et al. Protein adducts as prospective biomarkers of nevirapine toxicity[J]. Chemical research in toxicology, 2010, 23(11): 1714-1725.20809596
   
2. Jagadish B, Guntle G P, Zhao D, et al. Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetracetic acid derivatives[J]. Journal of medicinal chemistry, 2012, 55(23): 10378-10386.23148501