Arginase-1 (Rattus norvegicus)

Basic Information
Short Name	Arg1
UNP ID	P07824
Organism	Rattus norvegicus
Cys Site	Cys119, Cys168, Cys303
Family/Domain	Arginase family
Known Ligand	Ligand list
Function Type	Metabolic enzyme

Summary

Protein Function

Arginase, belongs to the ureohydrolase family of enzymes, which catalyses the conversion of arginine to urea and ornithine, exists as two distinct isoforms (arginase I and arginase II). Arginase I is expressed almost exclusively in the liver where it serves as an essential enzyme of the urea cycle, while arginase II is expressed in the kidney and many other extrahepatic tissues. Arginase catalyzes the fifth and final step in the urea cycle, a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. Specifically, arginase converts L-arginine into L-ornithine and urea. (From Wikipedia, PMID: 18488197)

Cys Function & Property

• Hydrophobic property:

• SASA：

Cys119: 0 A^2

Cys168: 15.433 A^2

Cys303: 0.158 A^2

Protein Sequence

MSSKPKPIEI IGAPFSKGQP RGGVEKGPAA LRKAGLVEKL KETEYNVRDH
GDLAFVDVPN DSPFQIVKNP RSVGKANEQL AAVVAETQKN GTISVVLGGD
HSMAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTSSGNL HGQPVAFLLK
ELKGKFPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYII KTLGIKYFSM
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPVF TPATGTPVVG
GLSYREGLYI TEEIYKTGLL SGLDIMEVNP TLGKTPEEVT RTVNTAVALT
LSCFGTKREG NHKPETDYLK PPK

Structural Information

• Known structure with covalent ligand:
  

Unknown

• Protein structure:

Related Pathway

• Arginine biosynthesis
  
• Arginine and proline metabolism
  
• Metabolic pathways
  
• Biosynthesis of amino acids
  
• Amoebiasis
  

Experimental Evidence

Homologous Analysis of Sequence, Cys Modification Assay

Reference

1. Kanda H, Sumi D, Endo A, et al. Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism[J]. Archives of toxicology, 2008, 82(11): 803. 18488197