Sentrin-specific protease 1

Basic Information
Short Name	SENP1
UNP ID	Q9P0U3
Organism	Homo sapiens
Cys Site	Cys603
Family/Domain	Peptidase C48 family
Known Ligand	Ligand list
Function Type	Protease

Summary

Protein Function

Sentrin-specific protease 1 (SENP1) catalyzes maturation SUMO protein (small ubiquitin-related modifier), which causes hydrolysis peptide bond of SUMO is in a conserved sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal to be added to the conjugation of other proteins (sumoylation). (From Wikipedia)

Cys Function & Property

Cys603 is one of the active sites of SENP1.

• Hydrophobic property:

• SASA:

Cys603: 0.105 A^2

Protein Sequence

MDDIADRMRM DAGEVTLVNH NSVFKTHLLP QTGFPEDQLS LSDQQILSSR
QGHLDRSFTC STRSAAYNPS YYSDNPSSDS FLGSGDLRTF GQSANGQWRN
STPSSSSSLQ KSRNSRSLYL ETRKTSSGLS NSFAGKSNHH CHVSAYEKSF
PIKPVPSPSW SGSCRRSLLS PKKTQRRHVS TAEETVQEEE REIYRQLLQM
VTGKQFTIAK PTTHFPLHLS RCLSSSKNTL KDSLFKNGNS CASQIIGSDT
SSSGSASILT NQEQLSHSVY SLSSYTPDVA FGSKDSGTLH HPHHHHSVPH
QPDNLAASNT QSEGSDSVIL LKVKDSQTPT PSSTFFQAEL WIKELTSVYD
SRARERLRQI EEQKALALQL QNQRLQEREH SVHDSVELHL RVPLEKEIPV
TVVQETQKKG HKLTDSEDEF PEITEEMEKE IKNVFRNGNQ DEVLSEAFRL
TITRKDIQTL NHLNWLNDEI INFYMNMLME RSKEKGLPSV HAFNTFFFTK
LKTAGYQAVK RWTKKVDVFS VDILLVPIHL GVHWCLAVVD FRKKNITYYD
SMGGINNEAC RILLQYLKQE SIDKKRKEFD TNGWQLFSKK SQEIPQQMNG
SDCGMFACKY ADCITKDRPI NFTQQHMPYF RKRMVWEILH RKLL

Structural Information

• Known structure with covalent ligand:
  

Unknown

• Protein structure:

Related Pathway

• RNA transport
  
• Wnt signaling pathway
  

Experimental Evidence

Homologous Analysis of Sequence, Enzymatic Assay

Reference

1. Qiao Z, Wang W, Wang L, et al. Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors[J]. Bioorganic & medicinal chemistry letters, 2011, 21(21): 6389-6392. 21930380
   
2. Ponder E L, Albrow V E, Leader B A, et al. Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors[J]. Chemistry & biology, 2011, 18(6): 711-721. 21700207