Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
| Basic Information | |
|---|---|
| Short Name | SERCA2, SR Ca2+-ATPase 2, Calcium pump 2 |
| UNP ID | P16615 |
| Organism | Homo sapiens |
| Cys Site | Cys674 |
| Family/Domain | Cation transport ATPase (P-type) family, Type IIA subfamily |
| Known Ligand | Ligand list |
| Function Type | Ion channel |
Summary
Protein Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. (From Uniprot)
SERCA Ca(2+)-ATPase is a intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. (From Wikipedia)
Cys Function & Property
Cys674 is very close to the ATP binding site in sequence.
- Hydrophobic property:
- SASA：
- Cys674: Unknown
Protein Sequence
MENAHTKTVE EVLGHFGVNE STGLSLEQVK KLKERWGSNE LPAEEGKTLL
ELVIEQFEDL LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILVA
NAIVGVWQER NAENAIEALK EYEPEMGKVY RQDRKSVQRI KAKDIVPGDI
VEIAVGDKVP ADIRLTSIKS TTLRVDQSIL TGESVSVIKH TDPVPDPRAV
NQDKKNMLFS GTNIAAGKAM GVVVATGVNT EIGKIRDEMV ATEQERTPLQ
QKLDEFGEQL SKVISLICIA VWIINIGHFN DPVHGGSWIR GAIYYFKIAV
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS
DKTGTLTTNQ MSVCRMFILD RVEGDTCSLN EFTITGSTYA PIGEVHKDDK
PVNCHQYDGL VELATICALC NDSALDYNEA KGVYEKVGEA TETALTCLVE
KMNVFDTELK GLSKIERANA CNSVIKQLMK KEFTLEFSRD RKSMSVYCTP
NKPSRTSMSK MFVKGAPEGV IDRCTHIRVG STKVPMTSGV KQKIMSVIRE
WGSGSDTLRC LALATHDNPL RREEMHLEDS ANFIKYETNL TFVGCVGMLD
PPRIEVASSV KLCRQAGIRV IMITGDNKGT AVAICRRIGI FGQDEDVTSK
AFTGREFDEL NPSAQRDACL NARCFARVEP SHKSKIVEFL QSFDEITAMT
GDGVNDAPAL KKAEIGIAMG SGTAVAKTAS EMVLADDNFS TIVAAVEEGR
AIYNNMKQFI RYLISSNVGE VVCIFLTAAL GFPEALIPVQ LLWVNLVTDG
LPATALGFNP PDLDIMNKPP RNPKEPLISG WLFFRYLAIG CYVGAATVGA
AAWWFIAADG GPRVSFYQLS HFLQCKEDNP DFEGVDCAIF ESPYPMTMAL
SVLVTIEMCN ALNSLSENQS LLRMPPWENI WLVGSICLSM SLHFLILYVE
PLPLIFQITP LNVTQWLMVL KISLPVILMD ETLKFVARNY LEPGKECVQP
ATKSCSFSAC TDGISWPFVL LIMPLVIWVY STDTNFSDMF WS
Structural Information
- Known structures with covalent ligands:
- Unknown
- Protein structure:
- Unknown
Related Pathway
- Calcium signaling patshway
- cGMP-PKG signaling pathway
- cAMP signaling pathway
- Cardiac muscle contraction
- Adrenergic signaling in cardiomyocytes
- Thyroid hormone signaling pathway
- Pancreatic secretion
- Alzheimer disease
- Hypertrophic cardiomyopathy (HCM)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Dilated cardiomyopathy (DCM)
Experimental Evidence
- Cys-directed Mutation, Cys Modifiaction Assay
Reference
- Lancel S, Zhang J, Evangelista A, et al. Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674[J]. Circulation research, 2009, 104(6): 720-723. 19265039
- Targets
- Homo sapiens
- Cation transport ATPase (P-type) family
- Type IIA subfamily
- Ion channel
- Calcium signaling pathway
- CGMP-PKG signaling pathway
- CAMP signaling pathway
- Cardiac muscle contraction
- Adrenergic signaling in cardiomyocytes
- Thyroid hormone signaling pathway
- Pancreatic secretion
- Alzheimer disease
- Hypertrophic cardiomyopathy (HCM)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Dilated cardiomyopathy (DCM)
