Protein-arginine deiminase type-3

Basic Information
Short Name	PADI3, PDI3
UNP ID	Q9ULC6
Organism	Homo sapiens
Cys Site	Cys646
Family/Domain	Protein arginine deiminase family
Known Ligand	Ligand list
Function Type	Metabolic enzyme

Summary

Protein Function

Peptidyl arginine deiminase, type III, also known as PADI3, is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. (From Wikipedia)

Cys Function & Property

Cys646 is the active site of PADI3. And this site is quite conserved in PADIs.

Alignment of PADIs' sequences

• Hydrophobic property:

• SASA：

Cys646: Unknown

Protein Sequence

MSLQRIVRVS LEHPTSAVCV AGVETLVDIY GSVPEGTEMF EVYGTPGVDI
YISPNMERGR ERADTRRWRF DATLEIIVVM NSPSNDLNDS HVQISYHSSH
EPLPLAYAVL YLTCVDISLD CDLNCEGRQD RNFVDKRQWV WGPSGYGGIL
LVNCDRDDPS CDVQDNCDQH VHCLQDLEDM SVMVLRTQGP AALFDDHKLV
LHTSSYDAKR AQVFHICGPE DVCEAYRHVL GQDKVSYEVP RLHGDEERFF
VEGLSFPDAG FTGLISFHVT LLDDSNEDFS ASPIFTDTVV FRVAPWIMTP
STLPPLEVYV CRVRNNTCFV DAVAELARKA GCKLTICPQA ENRNDRWIQD
EMELGYVQAP HKTLPVVFDS PRNGELQDFP YKRILGPDFG YVTREPRDRS
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSSGR RVTQVVRDFL
HAQKVQPPVE LFVDWLAVGH VDEFLSFVPA PDGKGFRMLL ASPGACFKLF
QEKQKCGHGR ALLFQGVVDD EQVKTISINQ VLSNKDLINY NKFVQSCIDW
NREVLKRELG LAECDIIDIP QLFKTERKKA TAFFPDLVNM LVLGKHLGIP
KPFGPIINGC CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
CRKPFSFKWW NMVP

Structural Information

• Known structure with covalent ligand:
  

Unknown

• Protein structure:

Unknown

Related Pathway

Unknown

Experimental Evidence

Homologous Analysis of Sequence, Mass Spectrometry

Reference

1. Jones J E, Slack J L, Fang P, et al. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors[J]. ACS chemical biology, 2011, 7(1): 160-165. 22004374